PROCESS FOR PREPARING NOVEL AMINE COMPOUND

Title:

PROCESS FOR PREPARING NOVEL AMINE COMPOUND

Document Type and Number:

Japanese Patent JPS51131839

Kind Code:

A

Abstract:

For the preparation of novel hydroxyamines of the formula (I) with the radicals as in Patent Claim 1, and of therapeutically acceptable acid addition salts of these compounds, a starting compound of the formula (II) is used. This is reacted with an amine of the formula (III) The resulting isomeric mixtures are separated into the pure isomers and the resulting racemates into the optical antipodes. The resulting free bases can be converted into their salts and the resulting salts converted into the corresponding free bases. Preferred compounds prepared are: 1) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(2-allylphenoxy)propan-2-ol, 2) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(2-methoxyethyl)phenoxy-propan-2 -ol, 3) 1-[1-methyl-2-(4-carbamylphenoxy)ethylamino]-3-(2-allyl-phenoxy)propan -2-ol, 4) 1-[1-methyl-2-(2-methylphenoxy)ethylamino]-3-(2-allylphenoxy)-propan-2 -ol, 5) 1-[1-methyl-2-(4-methylphenoxy)ethylamino]-3-(2-allylphenoxy)-propan-2 -ol, 6) 1-[1-methyl-2-(4-carbamylphenoxy)ethylamino]-3-(2-methylisonitrosometh ylphenoxy)propan-2-ol, 7) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(3-allylphenoxy)-propan-2-ol. The compounds have a blocking effect on beta -receptors and can be employed for the treatment of cardiovascular disorders.

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Inventors:

ENAA INGEMAA KAARUSON
GUSUTAFU BENIYUU ROOGERU SAMIY
AKUSERU KAARU GUNNAA OOBERUI

Application Number:

JP13134575A

Publication Date:

November 16, 1976

Filing Date:

October 31, 1975

Export Citation:

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Assignee:

HAESSLE AB

International Classes:

A61K31/13; A61K31/135; A61K31/138; A61K31/165; A61P9/06; A61P11/06; C07C67/00; C07C213/08; C07C217/32; C07C231/12; C07C235/08; C07C235/20; C07C235/46; C07C237/08; C07C239/00; C07D295/00; C07C241/00; C07C243/14; C07C243/32; C07C243/34; C07C251/48; C07C313/00; C07C313/04; C07D277/20; C07D277/34; C07D285/10; (IPC1-7): A61K31/165; A61K31/27; A61K31/275; A61K31/40; A61K31/425; A61K31/445; A61K31/495; A61K31/535; C07C93/06; C07C121/78; C07C125/06; C07C147/06; C07D277/34; C07D285/02; C07D295/10

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