Title:
PROCESS FOR PREPARING OXYCODONE HYDROCHLORIDE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE
Document Type and Number:
Japanese Patent JP2018184462
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a process for preparing an oxycodone hydrochloride composition having a reduced amount of 14-hydroxycodeinone.SOLUTION: The process comprises the steps of hydrogenating an oxycodone hydrochloride composition having at least 100 ppm 14-hydroxycodeinone in a suitable solvent such as alcohol with a hydrogen donor such as hydrogen gas, formic acid, indoline, and a catalyst to produce an oxycodone composition having less than 25 ppm 14-hydroxycodeinone.SELECTED DRAWING: None
Inventors:
CHAPMAN ROBERT
RIDER LONN S
HONG QI
KYLE DONALD
KUPPER ROBERT
RIDER LONN S
HONG QI
KYLE DONALD
KUPPER ROBERT
Application Number:
JP2018144003A
Publication Date:
November 22, 2018
Filing Date:
July 31, 2018
Export Citation:
Assignee:
EURO CELTIQUE SA
International Classes:
C07D489/08; A61K31/485; A61P25/04; C07D489/00
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki