Title:
PROCESS FOR PRODUCING CALCIUM SALT FORM OF STATIN
Document Type and Number:
Japanese Patent JP2009024008
Kind Code:
A
Abstract:
To provide a stable calcium salt of statin in a reduced steps easily reproducible and allowing a large-scale production.
Processes for producing a calcium salt of a statin from an ester derivative or protected ester derivative of the statin by using calcium hydroxide are provided. The ester or protected ester derivative is brought into contact with calcium hydroxide to obtain the calcium salt. Preferred statins are rosuvastatin, pitavastatin and atorvastatin, simvastatin and lovastatin. In processes beginning with a protected statin-ester derivative, the protecting group is hydrolyzed during salt formation by contact with calcium hydroxide, or is brought into contact with an acid catalyst followed by contact with calcium hydroxide.
Inventors:
NIDEAM-HILDESHEIM VALERIE
LIFSHITZ-LIRON REVITAL
LIDOR-HADAS RAMI
LIFSHITZ-LIRON REVITAL
LIDOR-HADAS RAMI
Application Number:
JP2008184147A
Publication Date:
February 05, 2009
Filing Date:
July 15, 2008
Export Citation:
Assignee:
TEVA PHARMA
International Classes:
C07C67/28; A61K31/22; C07C67/29; A61K31/351; A61K31/40; A61K31/404; A61K31/4418; A61K31/47; A61K31/4965; C07B61/00; C07C69/013; C07C69/03; C07C69/30; C07D207/34; C07D207/416; C07D209/12; C07D209/24; C07D213/30; C07D213/55; C07D215/14; C07D239/42; C07D309/30; C07F3/04
Domestic Patent References:
| JPS5356314A | 1978-05-22 | |||
| JPH02731A | 1990-01-05 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura