PROCESS FOR PRODUCING OPTICALLY ACTIVE TERTIARY ALCOHOL DERIVATIVE

Japanese Patent JP2014172839

A

PROBLEM TO BE SOLVED: To provide a process for producing a tertiary alcohol derivative of high optical purity from a racemic tertiary alcohol derivative or a tertiary alcohol derivative of low optical purity.SOLUTION: Provided is a method for producing an optically active tertiary alcohol, comprising: reacting a tertiary alcohol derivative such as (±)-methyl 2-hydroxy-3,3-dimethylbutanoate and an isocyanic acid ester such as isocyanic acid n-propyl isocyanate to convert a portion of the tertiary alcohol derivative into a carbamate in the presence of a metallic compound and a compound such as (s)-2,2-isopropylidene-bis(4-t-butyl-2-oxazoline) which can coordinate with a metallic compound; and separating the tertiary alcohol derivative which is not converted into a carbamate from the tertiary alcohol derivative which is converted into a carbamate.

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OKUMA TAKESHI
UEMIYA NOBUHITO
OOOKA HIROHITO

JP2013045569A

September 22, 2014

March 07, 2013

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UNIV HOKKAIDO
NIPPON SODA CO

C07C67/313; C07C69/675; C07C269/02; C07C271/12; C07B53/00; C07B57/00; C07B61/00; C07D263/28

JP2006036729A	2006-02-09
JP2006036729A	2006-02-09

JPN6016045324; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．　７６, 2011, ｐｐ．　１０３１２-１０３１８
JPN6016045325; 日本化学会第９３春季年会（２０１３）講演予稿集ＩＶ , 20130308, 第１３２２頁
JPN6016045324; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．　７６, 2011, ｐｐ．　１０３１２-１０３１８
JPN6016045325; 日本化学会第９３春季年会（２０１３）講演予稿集ＩＶ , 20130308, 第１３２２頁

Tadayuki Kikuma

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