Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE TERTIARY ALCOHOL DERIVATIVE
Document Type and Number:
Japanese Patent JP2014172839
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a process for producing a tertiary alcohol derivative of high optical purity from a racemic tertiary alcohol derivative or a tertiary alcohol derivative of low optical purity.SOLUTION: Provided is a method for producing an optically active tertiary alcohol, comprising: reacting a tertiary alcohol derivative such as (±)-methyl 2-hydroxy-3,3-dimethylbutanoate and an isocyanic acid ester such as isocyanic acid n-propyl isocyanate to convert a portion of the tertiary alcohol derivative into a carbamate in the presence of a metallic compound and a compound such as (s)-2,2-isopropylidene-bis(4-t-butyl-2-oxazoline) which can coordinate with a metallic compound; and separating the tertiary alcohol derivative which is not converted into a carbamate from the tertiary alcohol derivative which is converted into a carbamate.

Inventors:
OKUMA TAKESHI
UEMIYA NOBUHITO
OOOKA HIROHITO
Application Number:
JP2013045569A
Publication Date:
September 22, 2014
Filing Date:
March 07, 2013
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
HOKKAIDO UNIV
NIPPON SODA CO LTD
International Classes:
C07C67/313; C07C69/675; C07C269/02; C07C271/12; C07B53/00; C07B57/00; C07B61/00; C07D263/28
Domestic Patent References:
JP2006036729A2006-02-09
JP2006036729A2006-02-09
Foreign References:
Other References:
JPN6016045324; The Journal of Organic Chemistry vol. 76, 2011, pp. 10312-10318
JPN6016045325; 日本化学会第93春季年会(2013)講演予稿集IV , 20130308, 第1322頁
JPN6016045324; The Journal of Organic Chemistry vol. 76, 2011, pp. 10312-10318
JPN6016045325; 日本化学会第93春季年会(2013)講演予稿集IV , 20130308, 第1322頁
Attorney, Agent or Firm:
Tadayuki Kikuma