Title:
PROCESS FOR PRODUCING QUINUCLIDINES
Document Type and Number:
Japanese Patent JP2011088857
Kind Code:
A
Abstract:
To provide a process for producing cis-QMF which has a small environmental load and is industrially advantageous.
The process for producing a cis 2-alkylspiro(1,3-oxathiolane-5,3')quinuclidine hydrochloride comprises reacting a cis-trans isomeric mixture of a 2-alkylspiro(1,3-oxathiolane-5,3')quinuclidine with p-nitrobenzoic acid, then performing fractionation to obtain a cis-2-alkylspiro(1,3-oxathiolane-5,3')quinuclidine p-nitrobenzoate, and then converting this p-nitrobenzoate into the corresponding hydrochloride.
Inventors:
FUJITA MASAO
OTAYA KUMIKO
KITAGAWA YUTAKA
OTAYA KUMIKO
KITAGAWA YUTAKA
Application Number:
JP2009243947A
Publication Date:
May 06, 2011
Filing Date:
October 23, 2009
Export Citation:
Assignee:
DAIICHI FINE CHEM CO LTD
DAIICHI SANKYO CO LTD
DAIICHI SANKYO CO LTD
International Classes:
C07D453/00; A61K31/439; A61P1/02; A61P37/02; C07B57/00; C07B61/00
Domestic Patent References:
| JPH08319287A | 1996-12-03 | |||
| JPS61280497A | 1986-12-11 | |||
| JPS6445387A | 1989-02-17 | |||
| JPS6416787A | 1989-01-20 | |||
| JPH01104079A | 1989-04-21 |
Foreign References:
| US20080249312A1 | 2008-10-09 | |||
| US20090182146A1 | 2009-07-16 |
Other References:
JPN6010072106; ＩＬ ８１６５２ Ａ１ , 19910512
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
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