To provide a process for producing 7-amino-3-[2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid or its salt having a high Z-isomer content and a low content of phenylacetic acid or its derivative as an impurity.
Enzymatic reaction of a salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid is performed to obtain an aqueous solution containing phenylacetic acid or its derivative as a byproduct of the deprotection reaction, the phenylacetic acid or its derivative is extracted from the aqueous solution with an organic solvent or precipitated from the aqueous solution by crystallization, and the aqueous solution is brought into contact with activated carbon to increase the content of 7-amino-3-[2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid or its salt.
MATSUMOTO NOBUO
OHARA NOBUHIKO
TAKUBO YOSUKE
| JPH10101679A | 1998-04-21 | |||
| JP2005343854A | 2005-12-15 |
Yoshiyuki Matsushima