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Title:
PROCESS AND REACTION REAGENT FOR USE IN SYNTHESIS AND PURIFICATION OF OLIGONUCLEOTIDE
Document Type and Number:
Japanese Patent JP2008266331
Kind Code:
A
Abstract:

To provide a process and a reaction reagent for use in the synthesis and purification of an oligonucleotide.

The invention relates to a sulfur-transfer reaction reagent. The reagent is preferably embodied with 3-amino-1,2,4-dithiazolidine-5-one. The invention, in another aspect, relates to a preparation method for a phosphorothioate by treating a phosphite with the reagent, preferably with 3-amino-1,2,4-dithiazolidin-5-one as the reagent.


Inventors:
MANOHARAN MUTHIAH
JUNG MICHAEL E
RAJEEV KALLANTHOTTATHIL G
PANDEY RAJENDRA
WANG GANG
Application Number:
JP2008104337A
Publication Date:
November 06, 2008
Filing Date:
April 14, 2008
Export Citation:
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Assignee:
ALNYLAM PHARMACEUTICALS INC
International Classes:
C07C327/12; C07C327/16; C07C327/18; C07C333/08; C07C333/14; C07D207/327; C07D213/59; C07D213/83; C07D285/00; C07D285/01; C07D339/00; C07D339/04; C07D339/08; C07D495/04; C07D495/14; C07F9/6561; C07H21/00; C07H21/04; C12N15/09
Domestic Patent References:
JP2000510872A2000-08-22
JPH02304568A1990-12-18
JP2005515261A2005-05-26
JPS61167945A1986-07-29
JPH0647275A1994-02-22
JPH06279634A1994-10-04
JP2003064065A2003-03-05
JPH01283284A1989-11-14
JPS63281150A1988-11-17
JP2002501534A2002-01-15
JP2000510872A2000-08-22
JPH02304568A1990-12-18
JP2005515261A2005-05-26
JPS61167945A1986-07-29
JPH0647275A1994-02-22
JPH06279634A1994-10-04
JP2003064065A2003-03-05
JPH01283284A1989-11-14
JPS63281150A1988-11-17
JP2002501534A2002-01-15
Foreign References:
US5852168A1998-12-22
NL8902521A1991-05-01
WO1993013118A11993-07-08
US3276950A1966-10-04
WO1995025753A11995-09-28
DE2228364A11973-12-20
US3753908A1973-08-21
US3621030A1971-11-16
US3956303A1976-05-11
DE2404477A11975-08-07
EP0992506A22000-04-12
NL8902521A1991-05-01
WO1993013118A11993-07-08
US3276950A1966-10-04
WO1995025753A11995-09-28
DE2228364A11973-12-20
US3753908A1973-08-21
US3621030A1971-11-16
US3956303A1976-05-11
DE2404477A11975-08-07
EP0992506A22000-04-12
US5852168A1998-12-22
Other References:
JPN6010072001; Ｎｕｃｌｅｉｃ　Ａｃｉｄｓ　Ｒｅｓｅａｒｃｈ Ｖｏｌ．２３，Ｎｏ．２０, 1995, ｐ．４０２９-４０３３
JPN6010072002; Ｊｏｕｒｎａｌ　ｏｆ　Ｉｎｏｒｇａｎｉｃ　ａｎｄ　Ｎｕｃｌｅａｒ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４３，Ｎｏ．１１, 1981, ｐ．２７２９-２７３４
JPN6010072003; ＲＵＢＢＥＲ　ＣＨＥＭＩＳＴＲＹ　ＡＮＤ　ＴＥＣＨＮＯＬＯＧＹ Ｖｏｌ．１８, 1945, ｐ．１１０-１１５
JPN6012003438; Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．３８，Ｎｏ．５, 1994, ｐ．１０１５-１０２４
JPN6012003439; Ｃｈｅｍｉｓｃｈｅ　Ｂｅｒｉｃｈｔｅ Ｖｏｌ．１１４，Ｎｏ．２, 1981, ｐ．５４９-５６３
JPN6012003440; Ｚｅｉｔｓｃｈｒｉｆｔ　ｆｕｅｒ　Ｃｈｅｍｉｅ Ｖｏｌ．２２，Ｎｏ．１０, 1982, ｐ．３７７
JPN6012003441; Ｉｎｄｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｓｔｒｙ，　Ｓｅｃｔｉｏｎ　Ｂ：　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ　Ｉｎｃｌｕｄｉｎｇ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１７Ｂ，Ｎｏ．１, 1979, ｐ．１７-１９
JPN6010072001; Ｎｕｃｌｅｉｃ　Ａｃｉｄｓ　Ｒｅｓｅａｒｃｈ Ｖｏｌ．２３，Ｎｏ．２０, 1995, ｐ．４０２９-４０３３
JPN6010072002; Ｊｏｕｒｎａｌ　ｏｆ　Ｉｎｏｒｇａｎｉｃ　ａｎｄ　Ｎｕｃｌｅａｒ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４３，Ｎｏ．１１, 1981, ｐ．２７２９-２７３４
JPN6010072003; ＲＵＢＢＥＲ　ＣＨＥＭＩＳＴＲＹ　ＡＮＤ　ＴＥＣＨＮＯＬＯＧＹ Ｖｏｌ．１８, 1945, ｐ．１１０-１１５
JPN6012003438; Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．３８，Ｎｏ．５, 1994, ｐ．１０１５-１０２４
JPN6012003439; Ｃｈｅｍｉｓｃｈｅ　Ｂｅｒｉｃｈｔｅ Ｖｏｌ．１１４，Ｎｏ．２, 1981, ｐ．５４９-５６３
JPN6012003440; Ｚｅｉｔｓｃｈｒｉｆｔ　ｆｕｅｒ　Ｃｈｅｍｉｅ Ｖｏｌ．２２，Ｎｏ．１０, 1982, ｐ．３７７
JPN6012003441; Ｉｎｄｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｓｔｒｙ，　Ｓｅｃｔｉｏｎ　Ｂ：　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ　Ｉｎｃｌｕｄｉｎｇ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１７Ｂ，Ｎｏ．１, 1979, ｐ．１７-１９
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma



 
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