Title:
PROCESSES FOR PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF
Document Type and Number:
Japanese Patent JP2022107001
Kind Code:
A
Abstract:
To provide processes for preparing one or more solid forms of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, usable in the preparation of pharmaceutically acceptable solid formulations, and corresponding pharmaceutical compositions, and methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.SOLUTION: The present invention discloses a crystalline hydrate of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide.SELECTED DRAWING: None
Inventors:
AYMAN ALLIAN
JAYANTHY JAYANTH
MOHAMED-ESLAM F MOHAMED
MATHEW M MULHERN
FREDRIK LARS NORDSTROM
AHMED A OTHMAN
MICHAEL J ROZEMA
LAKSHMI BHAGAVATULA
PATRICK J MARROUM
PETER T MAYER
AHMAD Y SHEIKH
THOMAS B BORCHARDT
BEN KLUENDER
JAYANTHY JAYANTH
MOHAMED-ESLAM F MOHAMED
MATHEW M MULHERN
FREDRIK LARS NORDSTROM
AHMED A OTHMAN
MICHAEL J ROZEMA
LAKSHMI BHAGAVATULA
PATRICK J MARROUM
PETER T MAYER
AHMAD Y SHEIKH
THOMAS B BORCHARDT
BEN KLUENDER
Application Number:
JP2022079226A
Publication Date:
July 20, 2022
Filing Date:
May 13, 2022
Export Citation:
Assignee:
ABBVIE INC
International Classes:
C07D487/14; A61K9/22; A61K31/4985; A61K47/12; A61K47/38; A61P1/04; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P29/00; A61P37/02; A61P43/00; C07D207/08; C07D207/16; C07D487/04
Domestic Patent References:
| JP2013512280A | 2013-04-11 |
Foreign References:
| WO2015061665A1 | 2015-04-30 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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