PROCESSES FOR PREPARING N-HETEROARYL-N-ARYL-AMINE BY REACTING N-ARYL CARBAMIC ACID ESTER WITH HALO-HETEROARYL, AND ANALOGOUS PROCESSES

Title:

PROCESSES FOR PREPARING N-HETEROARYL-N-ARYL-AMINE BY REACTING N-ARYL CARBAMIC ACID ESTER WITH HALO-HETEROARYL, AND ANALOGOUS PROCESSES

Document Type and Number:

Japanese Patent JP2014133745

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide processes for producing diaryl amine compounds or salts thereof.SOLUTION: The present invention relates to processes for producing diaryl amine compounds of the formula (I) or salts thereof. The processes comprise coupling a compound of the formula (II) with an amine of the formula (III) in the presence of a transition metal catalyst or an alkali metal salt. Ar1 and Ar2 are independently Q; each Q is an aryl or heteroaryl ring system optionally fused to a saturated or unsaturated 5-8 membered ring having 0-4 heteroatoms; and Q is optionally substituted as defined in the claim 1. X is a leaving group; Y is -C(O)-O-Z; and Z is selected from C-Caliphatic, benzyl, Fmoc, -SOR' and Q, provided that Q is not substituted with X or alkyne; where R' is as defined in the claim 1.

Inventors:

SNOONIAN JOHN R
PATRICIA ANN OLIVER-SHAFFER

Application Number:

JP2014009078A

Publication Date:

July 24, 2014

Filing Date:

January 22, 2014

Export Citation:

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Assignee:

VERTEX PHARMA

International Classes:

C07D213/74; C07D213/56; C07D213/75; C07D213/80; C07D213/803; C07D213/82; C07B61/00; C07D213/79

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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