PROCESSES FOR PRODUCING AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND DISACCHARIDE AS IMMUNOEFFECTORS AND INTERMEDIATES THEREFOR

Title:

PROCESSES FOR PRODUCING AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND DISACCHARIDE AS IMMUNOEFFECTORS AND INTERMEDIATES THEREFOR

Document Type and Number:

Japanese Patent JP2010285446

Kind Code:

A

Abstract:

To provide processes for producing alkylamino glucosaminide phosphate compounds and disaccharide compounds functioning as immunoeffectors or adjuvants intended for vaccines and the like comprising various novel intermediates and intermediate steps.

A method for producing a glycosyl halide is provided which comprises the step of reacting an O-silyl glycoside with an α, α-dihalomethyl alkyl ether in the presence of an about stoichiometric or excess amount, in relation to the silyl glycoside, of an element selected from the group consisting of zinc chloride, zinc bromide, and boron trifluoride. Further, a method for producing a disaccharide is provided which comprises the step of coupling a glycosyl halide with a monosaccharide in the presence of a silver salt in order to form the disaccharide.

Inventors:

JOHNSON DAVID A
JOHNSON CRAIG L
BAZIN-LEE HELENE G
SOWELL C GREGORY

Application Number:

JP2010173257A

Publication Date:

December 24, 2010

Filing Date:

August 02, 2010

Export Citation:

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Assignee:

CORIXA CORP

International Classes:

C07H5/02; C07H5/06; C07H9/02; C07H11/04; C07H13/04; C07H13/06; C07H15/04; C07B61/00

Domestic Patent References:

JPH08245681A	1996-09-24
JPH0477496A	1992-03-11
JPH06293790A	1994-10-21
JPH0851998A	1996-02-27
JPS6469602A	1989-03-15
JP2001151790A	2001-06-05
JP2000256385A	2000-09-19
JP2002512623A	2002-04-23

Foreign References:

WO2001034617A2

2001-05-17

Other References:

JPN6012044795; Ｊ．Ｃ．Ｓ．　Ｐｅｒｋｉｎ　Ｔｒａｎｓ．１ , 1990, １３３９-１３５２
JPN6012044796; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔ．３４, 1993, ７１７５-７１７８
JPN6012044797; Ｏｒｇ．　Ｌｅｔｔ．３, 2001, ２０８１-２０８４
JPN6012044798; Ｔｅｔｒａｈｅｄｒｏｎ４６, 1990, ５９-６４
JPN6012044799; Ｂｉｏｏｒｇ．　Ｍｅｄ．　Ｃｈｅｍ．　Ｌｅｔｔ．４, 1994, ２８０５-２８１０
JPN6010004476; Ｊ．　Ｏｒｇ．　Ｃｈｅｍ．６２, 1997, ６０１２-６０２８
JPN6010004478; Ｂｉｏｏｒｇ．　Ｍｅｄ．　Ｃｈｅｍ．　Ｌｅｔｔ．９, 1999, ２２７３-２２７８
JPN6013007779; Ｐｒｏｔｅｃｔｉｖｅ　Ｇｒｏｕｐｓ　ｉｎ　Ｏｒｇａｎｉｃ　Ｓｙｎｔｈｅｓｉｓ２, 1991, ３２１-３２２，３３１-３３２，３５１-３５２，３５８-３５９

Attorney, Agent or Firm:

Hatsushi Shimizu
Koichi Niimi

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