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Title:
PROCESSES FOR PRODUCING AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND DISACCHARIDE AS IMMUNOEFFECTORS AND INTERMEDIATES THEREFOR
Document Type and Number:
Japanese Patent JP2010285446
Kind Code:
A
Abstract:

To provide processes for producing alkylamino glucosaminide phosphate compounds and disaccharide compounds functioning as immunoeffectors or adjuvants intended for vaccines and the like comprising various novel intermediates and intermediate steps.

A method for producing a glycosyl halide is provided which comprises the step of reacting an O-silyl glycoside with an α, α-dihalomethyl alkyl ether in the presence of an about stoichiometric or excess amount, in relation to the silyl glycoside, of an element selected from the group consisting of zinc chloride, zinc bromide, and boron trifluoride. Further, a method for producing a disaccharide is provided which comprises the step of coupling a glycosyl halide with a monosaccharide in the presence of a silver salt in order to form the disaccharide.


Inventors:
Johnson, David A.
Johnson, Craig L.
Bazin-lee, Helene G.
Sowell, Gregory C.
Application Number:
JP2010000173257
Publication Date:
December 24, 2010
Filing Date:
August 02, 2010
Export Citation:
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Assignee:
CORIXA CORP
International Classes:
C07H5/02; C07H5/06; C07H9/02; C07H11/04; C07H13/04; C07H13/06; C07H15/04; C07B61/00
Domestic Patent References:
JPH08245681A
JPH0477496A
JPH06293790A
JPH0851998A1996-02-27
JPS6469602A
JP2001151790A
JP2000256385A
JP2002512623A
Foreign References:
WO2001034617A2
Other References:
JPN6012044795; J.C.S. Perkin Trans.1 , 1990, 1339-1352
JPN6012044796; Tetrahedron Lett. 34, 1993, 7175-7178
JPN6012044797; Org. Lett. 3, 2001, 2081-2084
JPN6012044798; Tetrahedron 46, 1990, 59-64
JPN6012044799; Bioorg. Med. Chem. Lett. 4, 1994, 2805-2810
JPN6010004476; J. Org. Chem. 62, 1997, 6012-6028
JPN6010004478; Bioorg. Med. Chem. Lett. 9, 1999, 2273-2278
JPN6013007779; Protective Groups in Organic Synthesis 2, 1991, 321-322,331-332,351-352,358-359
Attorney, Agent or Firm:
清水 初志
新見 浩一