PURPOSE: To provide a processing method for perforations or the like by which not only perforations and slits can be applied but also curls can be reduced and its processing machine.

CONSTITUTION: A heating blade 88 for forming perforations or slits reciprocating along the crossing axis in right angles with a blister packing sheet A, is arranged in the cover film 61 side of the blister packing sheet A in which the cover film 61 is sealed on a vessel film 33 filled with articles in the pocket thereof. And a recession 89a containing a pocket and a plate 89 provided with a plate face enabling contact with the heated blade 88 are oppositely positioned against the heated blade 88, in the vessel film 33 side of the blister packing sheet A.