LXR調節イミダゾール誘導体のプロドラッグ

Title:

LXR調節イミダゾール誘導体のプロドラッグ

Document Type and Number:

Japanese Patent JP2014510110

Kind Code:

A

Abstract:

Imidazole prodrugs, pharmaceutically acceptable salts, or isomers thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

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Inventors:

Ellen Kay Kick
Michael Jay Hageman
Victor Earl Guarino
Chin-Chan Soo
Changkou way
Jayakmar Sankara Warrior
Satish kesavan naires

Application Number:

JP2014501296A

Publication Date:

April 24, 2014

Filing Date:

March 26, 2012

Export Citation:

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Assignee:

BRISTOL-MYERS SQUIBB COMPANY

International Classes:

C07D233/64; A61K31/4174; A61K31/675; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P17/00; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07F9/6506

Domestic Patent References:

JP2001526664A	2001-12-18
JP2008543971A	2008-12-04
JP2010520269A	2010-06-10

Foreign References:

WO2006066070A2	2006-06-22
US20070111971A1	2007-05-17
WO2010138598A2	2010-12-02

Other References:

JPN6015036461; Ａｄｖａｎｃｅｄ　Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｒｅｖｉｅｗｓ１９, 1996, ｐｐ．１１５-１３０
JPN6015036464; Ｎａｔｕｒｅ　Ｒｅｖｉｅｗｓ／Ｄｒｕｇ　Ｄｉｓｃｏｖｅｒｙ７（３）, 2008, ｐｐ．２５５-２７０
JPN6015036469; Ｐｏｖｌ　Ｋｒｏｇｓｇａａｒｄ-Ｌａｒｓｅｎ，　ｅｔ　ａｌ．: Ｔｅｘｔｂｏｏｋ　ｏｆ　Ｄｒｕｇ　Ｄｅｓｉｇｎ　ａｎｄ　Ｄｉｓｃｏｖｅｒｙ　Ｔｈｉｒｄ　Ｅｄｉｔｉｏｎ , 2005, ｐｐ．４６０-５１４, Ｔａｙｌｏｒ　＆　Ｆｒａｎｃｉｓ

Attorney, Agent or Firm:

Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Mizuhara Masahiro

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