Title:
医薬的特性が改善されたプロドラッグペプチド
Document Type and Number:
Japanese Patent JP7046990
Kind Code:
B2
Abstract:
The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide or peptidomimetic, wherein the biological property is selected from the group consisting of therapeutic index, stability, solubility, toxicity, adsorption, and pre-systemic metabolism. The pro-drug peptide comprising the following structure: Z-pep, wherein: pep is the parent peptide or peptidomimetic; Z is a sequence of n amino acids, Z is cleaved in vivo releasing pep; n≥2 amino acids. The present disclosure also relates to methods of making and using the pro-drug peptide of the present disclosure. For example, the present disclosure describes a pro-drug peptide that may be used to prevent, treat, or ameliorate at least one symptom of hypoglycemia or a hypoglycemia-related disease or disorder.
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Inventors:
Jimer, Robert Ash
Gilles, Jill
Flemo, juliet
Benin, claire
Goodrow, Sebastian
Gilles, Jill
Flemo, juliet
Benin, claire
Goodrow, Sebastian
Application Number:
JP2019572117A
Publication Date:
April 04, 2022
Filing Date:
June 29, 2018
Export Citation:
Assignee:
UREKA SARL
International Classes:
C07K14/605; A61K38/26; A61K47/65; A61P3/08; C12P21/02
Domestic Patent References:
| JP6503473A | ||||
| JP2010536341A | ||||
| JP2014525901A | ||||
| JP2006525235A |
Foreign References:
| US20110288001 | ||||
| WO2016049174A1 | ||||
| WO2007056362A2 |
Attorney, Agent or Firm:
Fukami patent office