PRODRUG TYPE MEDICINE COMPOSITION AND MANUFACTURE

Japanese Patent JPS61263916

A

Pharmaceutical compositions of the prodrug type, a process for the preparation thereof, a process for the preparation of the as prodrug functioning compounds and compounds obtained herein.The pharmaceutical compositions of the inven-' tion contain organic acid anhydrides with formula 1 through 5, as well as the pharmacological acceptable salts thereof as prodrug functioning compounds, together with a suitable pharmaceutically acceptable gaseous,liquid or solid carrier.The prodrug systems of the invention possess as favourable property that they amend the residence time of the pharmaceutical composition in the body by influencing the transport system.Furthermore they increase the biological availability because of the more lipophilic properties of the anhydride compared with the acid, so that this improved administration performance may contribute to lower dosages.Further the prodrug systems according to the invention contribute to the reduction of the complaints of patients, because the systems usually remove the unpleasant bitter taste and the flavour, whereas the gastro intestinal irritation of the organic acids is removed or reduced.

FURANSU HERUUIGU JIYAN JIYANSE
ETEIINE YATSUKOI DEKOTSUKU

JP11178486A

November 21, 1986

May 15, 1986

Click for automatic bibliography generation  

BA INPHARM BV

A61K31/185; A61K31/43; A61K31/56; A61K31/575; A61P1/16; A61P25/04; A61P25/08; A61P29/00; C07D519/06; A61P31/04; A61P43/00; C07C51/567; C07C53/126; C07C53/128; C07C57/30; C07C62/06; C07D499/00; C07D519/00; C07J9/00; (IPC1-7): A61K31/185; A61K31/43; A61K31/56; A61K31/575; C07C53/126; C07C57/30; C07D499/46; C07D519/00

Yoshihiro Morimoto

Previous Patent: PRODUCTION OF SUGAR-COATED SOLID FORMULATION

Next Patent: CEREBRAL FUNCTION NORMALIZING AGENT