To easily obtain the subject compound useful as a raw material for new antibiotics in a high purity and in a high yield by treating pentitol with an acid and subsequently subjecting the treated product to a dehydrative cyclization reaction in a solvent capable of forming an azeotropic mixture with water.
(A) 2-Deoxy-D-erythro-pentitol is treated with (B) an acid (preferably an arylsulfonic acid) and subsequently subjected to a dehydrative cyclization reaction based on the azeotropic principle in (C) a solvent (preferably toluene) capable of forming an azeotropic mixture with water to obtain (D) 1,4-anhydro-2- deoxy-D-erythro-pentitol. The component A is obtained by hydrogenating 2- deoxy-D-ribose in the presence of a Raney catalyst (preferably Raney nickel catalyst).
KIKUCHI SATOSHI
IRIUCHIJIMA SHINOBU
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