To obtain 1,5-benzodiazepine derivative, useful as an intermediate for a pharmaceutical compound for angina pectoris, etc., by using a specific new compound as a raw material.
This 1,5-benzodiazepine derivative of formula II [ring A and ring B are each a (substituted) benzene ring; R1 and R2 are each H, carbamoyl, etc.; R3 is H, a di-(lower alkyl) amino(lower alkyl), etc.] or its salt is obtained by subjecting a propionic acid amide expressed by formula I or its salt to an intramolecular ring closing reaction. The reaction is carried out in the presence of an acid such as a Broensted acid or a base such as alkali metal hydrogencarbonate in a solvent such as methanol at 0-250°C. Further, a new compound of formula I is obtained by reacting 2-aminothiophenol derivative of formula III with 2,3-epoxypropionic acid amide derivative of formula IV.
YOSHIOKA RYUZO
SHIBATANI TAKEJI
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