Title:
PRODUCTION OF 211HYDROXYY 166PREGNENN200ONE DERIVATIVES
Document Type and Number:
Japanese Patent JPS51138668
Kind Code:
A
Abstract:
DELTA 16-21-HYDROXY-20-KETO STEROIDS OF THE PREGNANE SERIES HAVING AN OTHERWISE UNSUBSTITUTED D-ring and a 13-methyl or -ethyl group, and 21-ethers and -esters thereof, are produced by reaction of a corresponding D-ring saturated 17-keto steroid with a lithium compound of the formula thereby converting the 17-keto group to a 17 beta -hydroxy-20 alpha -enol ether in which the 17 alpha -side chain has the formula wherein R3 and R4 have the values given above, and, in any desired sequence, splitting off R3 and/or R4 enol ether by hydrolysis; eliminating 17 beta -hydroxy group, preferably after acylation, with formation of a DELTA 16-double bond; and, if desired, splitting off any blocking group.
Inventors:
ROOBERUTO NIKORUSON
Application Number:
JP5311676A
Publication Date:
November 30, 1976
Filing Date:
May 10, 1976
Export Citation:
Assignee:
SCHERING AG
International Classes:
C07J1/00; C07J13/00; C07J17/00; (IPC1-7): C07J5/00