Title:
PRODUCTION OF 2,2,6,6-TETRAHALOCYCLOHEXANIMINE DERIVATIVE
Document Type and Number:
Japanese Patent JPH01117852
Kind Code:
A
Abstract:
PURPOSE:To obtain the above compound useful as a synthetic intermediate for 2,6-dihaloaniline derivative known as pharmaceuticals and agricultural chemicals, in high yield, by reacting 2,2,6,6-tetrahalocyclohexanone with a primary amine or ammonia in the presence of a Lewis acid. CONSTITUTION:The objective compound of formula (R is H, alkyl or aromatic group; X is halogen) can be produced by the dehydrative condensation reaction of 2,2,6,6-tetrahalocyclohexanone with a primary amine (e.g., methylamine) or ammonia in the presence of a Lewis acid (e.g., titanium tetrachloride) as a catalyst at -10-+50 deg.C. The amount of the Lewis acid is 0.25-2.0mol. per 1mol. of tetrahalocyclohexanone. The objective compound is produced from an inexpensive raw material in short steps. The tetrahalocyclohexanone used as a starting raw material can be produced by the halogenation of cyclohexanone which is easily available at a low cost.
Inventors:
SAEKI TAKEAKI
ISHIKAWA HIDEO
OKI TSUNEBEE
ISHIKAWA HIDEO
OKI TSUNEBEE
Application Number:
JP27720687A
Publication Date:
May 10, 1989
Filing Date:
October 30, 1987
Export Citation:
Assignee:
OSAKA ORGANIC CHEM IND
International Classes:
C07C211/52; B01J27/10; C07B61/00; C07C67/00; C07C209/00; C07C209/52; C07C209/60; C07C211/56; C07C241/00; C07C249/02; C07C251/20; C07C257/02; (IPC1-7): B01J27/10; C07B61/00; C07C85/00; C07C87/60; C07C119/16
Attorney, Agent or Firm:
Sota Asahina (1 person outside)