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Title:
PRODUCTION OF 2,3,5-TRIMETHYLBENZOQUINONE
Document Type and Number:
Japanese Patent JPS63280040
Kind Code:
A
Abstract:

PURPOSE: To industrially obtain the titled compound which is an intermediate for medicines, by oxidizing 2,3,6-trimethylphenyl in the presence of a catalyst of cupric chloride and lithium chloride using a mixture solution of an aromatic hydrocarbon and lower aliphatic alcohol as a solvent.

CONSTITUTION: 2,3,5-Trimethylphenol is oxidized with preferably molecular oxygen in the presence of cupric chloride and lithium chloride as a catalyst (preferably an aqueous solution) using a mixture solution of an aromatic hydrocarbon, such as benzene, toluene, xylene or chlorobenzene, and a 1W4C aliphatic alcohol, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, 2-butanol or tert.-butanol, as a solvent to afford 2,3,5-trimethylbenzoquinone. Since the inexpensive reusable catalyst is used, good yield is obtained. The solvent can also be reused and the resultant product is useful as a synthetic intermediate for medicines, such as vitamin E.


Inventors:
HIROSE NORIYASU
HAMAMURA KICHISABURO
INAI YUICHI
EMA KIICHI
BANBA TAKASHI
KIJIMA SHIZUMASA
Application Number:
JP11666587A
Publication Date:
November 17, 1988
Filing Date:
May 13, 1987
Export Citation:
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Assignee:
EISAI CO LTD
International Classes:
C07B61/00; C07C45/00; C07C46/08; B01J27/122; C07C50/02; C07C50/04; C07C67/00; (IPC1-7): B01J27/122; C07C46/08; C07C50/02
Attorney, Agent or Firm:
Kaoru Furuya