PURPOSE: To simply obtain the subject compound useful as a synthetic intermediate for HMG-CoA reductase inhibitor having decalin skeleton by irradiating Z configuration based on propenyl group at the 6-position of a naphthalene derivative with light rays.
CONSTITUTION: Z Configuration based on propenyl group at the 6-position of a (2S,4aR,6S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-2-methyl-6-((e)-l-propenyl)naphthalene derivative of formula I [R1 is H, OH-protecting group; 2-6C alkanoyl or aroyl; R2 is oxycarbonyl of COOR3 (R3 is H, 1-5C alkyl, etc.) or oxymethyl of CH2OR4 (R4 is H or OH-protecting group)] is irradiated with light rays by using a high- pressure mercury vapor lamp in the presence of a radical initiator (e.g. diphenyl disulfide) in a solvent (e.g. benzene) to give the objective compound of formula II.
INABA TAKAYUKI
SUGIMOTO KIKUO
TERAJIMA ATSURO
SHIOZAKI MAKOTO
