Title:
PRODUCTION OF 3ALPHA,16ALPHA-APOVINCAMINIC ACID ESTER
Document Type and Number:
Japanese Patent JPH01199970
Kind Code:
A
Abstract:
PURPOSE:To obtain the title compound which has vasodilative action through a one-stage reaction with simple operations by conducting a condensation reaction of 3alpha,16alpha-apovincaminic acid with a lower alcohol using 1,3-dialkyl-2- halogeno-imidazolinium halogenide as a condensation reagent. CONSTITUTION:The reaction of 3alpha,16alpha-apovincaminic acid with a lower alcohol is carried out, using 1,3-dialkyl-2-halogeno-imidazolinium halogenide such as 1,3-dimethyl-2-chloroimidazolinium chloride as a condensation agent, to obtain a 3alpha,16alpha-apovincaminic acid ester such as ethyl 3alpha,16alpha-apovincaminate. The reaction proceeds quantitatively at room temperature to give the subject compound in high yield.
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Inventors:
HIROTA HIROSHI
MIYAGAKI MITSUHIRO
MIYAGAKI MITSUHIRO
Application Number:
JP2462388A
Publication Date:
August 11, 1989
Filing Date:
February 04, 1988
Export Citation:
Assignee:
SHIRATORI PHARM
International Classes:
C07D461/00; (IPC1-7): C07D461/00
Attorney, Agent or Firm:
Miyuki Ariga (2 outside)
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