Title:
PRODUCTION OF 4-ALKOXYCARBONYL-5-AMINO-1-METHYLPYRAZOLE
Document Type and Number:
Japanese Patent JP3489125
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject compound useful as an intermediate for medicines and agrichemicals, especially a raw material for herbicides of agrichemical in high qualities and high yield by reacting an alkoxymethylenecyanoacetic acid alkyl ester with methylhydrazine.
CONSTITUTION: A 1-4C alkoxymethylenecyanoacetic acid alkyl ester of formula I (R1 and R2 are 1-4C alkyl) is reacted with 30-40% aqueous solution of methylhydrazine in an aromatic solvent (e.g. toluene) by gradually heating up to 40-90°C and slowly reducing pressure up to 150-3mmHg to give the objective compound of formula II. The amount of methylhydrazine used is 1.0-1.3 mols based on 1 mol of the compound of formula I. Water and a formed 1-4C alkanol can be removed by gradually heating and slowly reducing the pressure in the reaction.
Inventors:
Hideki Takamatsu
Fumio Suzuki
Eiichi Ohya
Susumu Yamamoto
Fumio Suzuki
Eiichi Ohya
Susumu Yamamoto
Application Number:
JP23361992A
Publication Date:
January 19, 2004
Filing Date:
September 01, 1992
Export Citation:
Assignee:
Nissan Chemical Industry Co., Ltd.
International Classes:
C07D231/38; (IPC1-7): C07D231/38
Domestic Patent References:
| JP60181087A |
Other References:
Ａｕｓｔｒａｌｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ，３６（１） ｐｐ１３５−１４７ （１９８３）
Ｊ．Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍ．，２４（３） ｐｐ６９３−５ （１９８７）
Ｊ．Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍ．，２４（３） ｐｐ６９３−５ （１９８７）