PRODUCTION OF 4-ALKOXYINDOLE DERIVATIVE

Title:

PRODUCTION OF 4-ALKOXYINDOLE DERIVATIVE

Document Type and Number:

Japanese Patent JPH04134064

Kind Code:

A

Abstract:

PURPOSE: To readily and efficiently obtain a compound useful as intermediates for synthesis of various medical drugs by treating pyrrole derivative with an acid in the presence of alcohols.

CONSTITUTION: A pyrrole derivative expressed by formula I (Ar is phenyl) or an acetal substance of said derivative is treated with an acid (e.g. sulfuric acid) in the presence of a compound expressed by the formula R1 OH [R1 is 1-5C alkyl, aralkyl, hydroxy 1-5C alkyl or R2CH2CH(OH)CH2-(R2 is eliminating group)] to afford the aimed indole derivative expressed by formula II. The reaction is performed in a solvent such as dichloromethane with refluxing in heating. As a compound expressed by the formula R1OH, 1,3-propanediol is exemplified. Thereby, formation of indole ring and introduction of 4-alkoxy group are attained at once not by way of 4-hydroxyindole unstable in air, thus simplification of the reaction process is attained.

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Inventors:

NATSUME MITSUTAKA
MURATAKE HIDEAKI
FUJI MASAHIRO

Application Number:

JP25605090A

Publication Date:

May 07, 1992

Filing Date:

September 25, 1990

Export Citation:

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Assignee:

OTSUU KENKIYUUSHIYO
SHIONOGI & CO

International Classes:

C07D207/48; C07D209/08; (IPC1-7): C07D207/48; C07D209/08

Attorney, Agent or Firm:

Aoyama Ryo (2 outside people)

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