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Title:
PRODUCTION OF 4-HYDROXYPHENYLPROPIONIC ACID COMPOUND OR ESTER THEREOF
Document Type and Number:
Japanese Patent JPS63227542
Kind Code:
A
Abstract:

PURPOSE: To obtain the titled compound which is a synthetic intermediate for medicines, etc., in high purity, by de-tert-butylating a readily available 3-(3,5- ditertiary butyl-4-hydroxyphenyl)propionic acid as a raw material in the presence of an acidic substance.

CONSTITUTION: 3-(3,5-Ditertiary butyl-4-hydroxyphenyl)propionic acid or an ester thereof is used as a raw material and de-tert-butylated in the presence of an acidic substance, such as sulfuric acid or trifluoroacetic acid, in a solvent, such as benzene or chloroform, while cooling or at a temperature of room temperature W boiling point of the solvent used to afford the aimed compound expressed by the formula (R1 is H or tertiary butyl; R2 is H or alkyl).


Inventors:
ONISHI AKIYOSHI
ISHIMARU KATSUTOSHI
Application Number:
JP6221487A
Publication Date:
September 21, 1988
Filing Date:
March 17, 1987
Export Citation:
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Assignee:
YOSHITOMI PHARMACEUTICAL
MITSUBISHI PETROCHEMICAL CO
International Classes:
C07C69/732; B01J27/02; B01J27/06; C07B61/00; C07C51/353; C07C59/52; C07C67/30; (IPC1-7): B01J27/02; B01J27/06; C07C51/353; C07C59/52; C07C67/30; C07C69/732
Attorney, Agent or Firm:
Takashima Hajime