Title:
PRODUCTION OF 6-GUANIDINOCAPROIC P-ETHOXYCARBONYLPHENYL ESTER P-TOSYLATE
Document Type and Number:
Japanese Patent JPS57140759
Kind Code:
A
Abstract:
PURPOSE: p-Tosylate salt of mixed acid anhydride of 6-guanidinocaproic acid with p-tosylic acid is made to reat with p-hydroxybenzoic ethyl ester to produce the titled compound used as an intermediate of gabexate mesylate under mild reaction conditions in high yield.
CONSTITUTION: p-Tosylate salt of acid nhydride between 6-guanidinocaproic acid and p-tosylic acid of formula 2 is made to react with p-hydroxybenzoic ethyl ester of formula 3 usually at room temperature to 50°C for about 1 hour to give the objective compound of formulaI. The amount of p-hydroxybenzoic ethyl ester used is equal to or more than the p-tosylate salt in molar quantities.
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Inventors:
SATOIE KAZUO
Application Number:
JP2651881A
Publication Date:
August 31, 1982
Filing Date:
February 25, 1981
Export Citation:
Assignee:
TOHO IYAKU KENKYUSHO KK
International Classes:
C07C279/14; C07C67/00; C07C301/00; C07C303/22; C07C309/42; (IPC1-7): C07C143/42