Title:
PRODUCTION OF 9 ALPHAA FLUORRSTEROID AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPS5214761
Kind Code:
A
Abstract:
Novel 11,12-unsaturated 9 alpha -fluorosteroids, especially those of the androstane and pregnane series, with the following constitution in rings B and C it being possible for all the substituents customary in the known pharmacological active steroids to be present in the remaining positions in the steroid framework and in the side chain, are prepared. Compounds of this type generally display pharmacological effects analogous to those of the corresponding known compounds; for example the derivatives derived from the known corticosteroids display a potent antiinflammatory effect with a relative reduction in the unwanted effect on the adrenals, thymus and body weight. The novel compounds are obtained by a novel type of chemical process, namely from corresponding 9 alpha -fluoro-11 beta -hydroxysteroids by dehydration using an N,N-disubstituted aminosulphur trifluoride. This process is generally applicable to the preparation of any desired 11,12-unsaturated 9 alpha -fluorosteroids.
Inventors:
MISHIERU BIORA
YAROSURAFU KARUFUODA
YAROSURAFU KARUFUODA
Application Number:
JP8737176A
Publication Date:
February 03, 1977
Filing Date:
July 23, 1976
Export Citation:
Assignee:
CIBA GEIGY AG
International Classes:
C07J75/00; C07J1/00; C07J5/00; C07J7/00; C07J21/00; C07J71/00; (IPC1-7): C07J1/00