PRODUCTION OF 9ALPHA-HYDROXY-4-ANDROSTENE-3,17-DIONE, AND MYCOBACTERIUM ROSEUM SPECIES TO BE USED THEREFOR

Title:

PRODUCTION OF 9ALPHA-HYDROXY-4-ANDROSTENE-3,17-DIONE, AND MYCOBACTERIUM ROSEUM SPECIES TO BE USED THEREFOR

Document Type and Number:

Japanese Patent JPS6485099

Kind Code:

A

Abstract:

PURPOSE: To obtain 9α-hydroxy-4-androstene-3,17-dione by decomposing the side chain of a naturally occurring sterol with new microorganisms belonging to the genus Mycobacterium.

CONSTITUTION: An 1,2-steriod dehydrogenase-deleted strain of Mycobacterium roseum species capable of decomposing the side chain of naturally occurring sterols, pref. Mycobacterium roseum sp. rov. 1108/1 (NCAIM B (P) 000339), is subjected to aerobic fluid fermentation in an agar medium with a (2:1) mixture of naturally occurring sterols, e.g. β-sitosterol and campesterol, as substrate, and the objective 9α-hydroxy-4-androstene-3,17-dione formed is collected.

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Inventors:

ANTOONIYA ETSUKERU NEEE BOKAAN
KAARORII ARUBURECHIYUTO
GAABORU AMUBURUSHIYU
TEIBORU RAANGU
ISHIYUTOBUAAN MIHAARII SABOO
EEBUA IRUKOOEEI
EEBUA CHIYAYAAJI
KAARUMAN KENTSUERU
IMURE MORAFUCHIKU
GAABORU HANTOSHIYU
EMURIA SHIMONOBUITSUCHI
SUZANNA RENJIERU NEEE SEMENIEI
ZUZANNA BUIDA

Application Number:

JP29166587A

Publication Date:

March 30, 1989

Filing Date:

November 18, 1987

Export Citation:

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Assignee:

RICHTER GEDEON VEGYESZET

International Classes:

C12P33/00; C12P33/16; C12N1/20; C12R1/32; (IPC1-7): C12N1/20; C12P33/16

Attorney, Agent or Firm:

Soichi Takezawa

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