PURPOSE: To advantageously obtain the subject compound by reacting the corresponding aldehydes with hydrogen cyanide, then reacting the resultant product with ammonia in acetonitrile and further depositing the obtained product as a hydrochloride with hydrochloric acid in acetonitrile.
CONSTITUTION: A compound expressed by formula I (R and R1 are H, halogen or 1-6C alkyl; X is O or S) is reacted with hydrogen cyanide to provide a compound specific formula II, which is then reacted with ammonia in acetonitrile to afford a compound expressed by formula III. The resultant compound is further reacted with hydrochloric acid in acetonitrile and deposited as hydrochloride to industrially and advantageously provide the objective compound expressed by formula IV useful as a raw material for agricultural chemicals and medicines in high purity and yield without using special reaction reagents and carrying out operation, such as removal of the solvent or substitution, and deterioration in yield by decomposition or coloring of unstable α- aminoacetonitriles.
TANAKA YOSHINORI
KONO TOSHIYUKI
WATANABE SEIICHI
ISHIKAWA KATSUTOSHI
