Title:
PRODUCTION OF ALPHA-HYDROXYISOBUTYRAMIDE
Document Type and Number:
Japanese Patent JPH05244968
Kind Code:
A
Abstract:
PURPOSE: To efficiently produce α-hydroxyisobutyramide from acetone cyanhydrin and to prepare an α,β-unsaturated carboxylic acid aliphatic alcohol ester or an α,β-unsaturated carboxylic acid by using the amide.
CONSTITUTION: Acetone cyanhydrin is treated in an aqueous medium with a culture solution of a microorganism capable of forming a hydroxyisobutyramide from acetone cyanhydrin, cells or a treated material of the cells to produce α-hydroxyisobutyramide. The amide is reacted with water and/or an aliphatic alcohol in the presence of a solid acid catalyst at 150°C in a gas phase or a gas-liquid mixed phase to prepare an α,β-unsaturated carboxylic acid aliphatic alcohol ester or an α,β-unsaturated carboxylic acid.
Inventors:
ISHIWATARI KENICHI
SHIMADA MASAO
HATAMORI AKIRA
SHIMADA MASAO
HATAMORI AKIRA
Application Number:
JP18369992A
Publication Date:
September 24, 1993
Filing Date:
July 10, 1992
Export Citation:
Assignee:
MITSUI TOATSU CHEMICALS
International Classes:
C07C57/04; C07C231/06; C12P13/02; C12R1/01; C12R1/025; C12R1/06; C12R1/365; C12R1/39; (IPC1-7): C12P13/02