Title:
PRODUCTION OF AMINES
Document Type and Number:
Japanese Patent JP3803185
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To easily obtain, in a high yield and in an industrially advantageous way, amines useful as intermediates, for medicines and agrochemicals by treating a specific substituted amides with a reducing agent composed of a specific halide and a metal borohydride.
SOLUTION: The amines of formula II [e.g. (R)-N-(α-methyl-3- methyoxybenzyl)-3-(2-chlorophenyl)-1-propylamine] is obtained by treating substituted amides of formula I [R1 to R3 are each H, a (substituted) 1-20C alkyl or the like] [e.g. (R)-N-(α-methyl-3-methoxybenzyl)-3-(2-chlorophenyl) propionamide] with a reducing agent composed of a compound of the formula R4X (R4 is H or a 1-3C alkyl; X is a halogen) and a metal borohydride (pref. e.g. composed of sodium borohydride and methyl iodide) in the presence (absence) of an organic solvent such as tetrahydrofuran, pref. at a temp. of 50-55°C for 1-4 h.
Inventors:
Maruo Masafumi
Kenji Saito
Koji Hayashi
Tokuro Yoneya
Kenji Saito
Koji Hayashi
Tokuro Yoneya
Application Number:
JP31220297A
Publication Date:
August 02, 2006
Filing Date:
November 13, 1997
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
International Classes:
C07B43/04; C07C211/27; C07C209/50; C07C213/02; C07C217/58; (IPC1-7): C07C211/27; C07B43/04; C07C209/50; C07C213/02; C07C217/58
Domestic Patent References:
| JP7303496A |
Attorney, Agent or Firm:
Yoshinori Hosoda
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