Title:
PRODUCTION OF AMINOCHLOROPURINE
Document Type and Number:
Japanese Patent JP3064035
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject compound useful as an intermediate for synthesizing pharmaceutical compounds such as guanine nucleotide analogues by reacting guanine with a chlorinating agent in the presence of a dialkylaniline.
CONSTITUTION: Guanine is reacted with a chlorinating agent (e.g. phosphorus oxychloride) in the presence of a dialkylaniline (e.g. N,N-diethylaniline) preferably in a solvent-free state at 70-120°C for 20min to several hr to obtain 2- amino-6-chloropurine of the formula. The chlorinating agent and the dialkylaniline are used in amounts of 3-10 times moles and ≥2 times moles, respectively, the amount of the guanine.
Inventors:
Tadashi Sato
Application Number:
JP10357291A
Publication Date:
July 12, 2000
Filing Date:
April 10, 1991
Export Citation:
Assignee:
Kojin Co., Ltd.
International Classes:
C07D473/40; (IPC1-7): C07D473/40