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Title:
PRODUCTION OF ANTIBIOTIC,3',4'-DIDEOXYBUTIROSIN
Document Type and Number:
Japanese Patent JPS5542586
Kind Code:
A
Abstract:

PURPOSE: A specific mold of Bacillus is cultured to produce aminoglycoside antibiotics, 3',4'-dideoxybutirisin(DDB)-A and B.

CONSTITUTION: A neamine-dependent mutant producing butirosin typified by Bacillus circulans MCRL 5003 (FERM-3346) is cultured in the presence of 3', 4'- dideoxyneamine or 3',4'-dideoxyribostamycin and the objective DDB-A and B are isolated from the culture medium or converted into their salts by usual methods.

EFFECT: Said antibiotics are effective against gramm-positive and negative bacteria including Pseudomonas aeruginosa as well as clinically separated molds resisting gentamicin and dibekacin. Further they are relatively low toxic among aminoglycoside antibiotics.


Inventors:
TAKEDA KATSUO
KINUMAKI AKIO
KOMAI TAMOTSU
YAMAGUCHI TOUTAROU
OOSHIMA SATOSHI
ITOU YUKIO
Application Number:
JP11718578A
Publication Date:
March 25, 1980
Filing Date:
September 22, 1978
Export Citation:
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Assignee:
TANABE SEIYAKU CO
International Classes:
C12P19/50; C12R1/09; (IPC1-7): C12P19/50; C12R1/09



 
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