Title:
PRODUCTION OF BACAMPICILLIN-6BETA-HALOPENICILLANATE
Document Type and Number:
Japanese Patent JPS6219592
Kind Code:
A
Abstract:
PURPOSE: To obtain the titled compound in stable crystal without admixture of impurities, etc., useful as a β-lactamase inhibitor, by reacting bacampicillin hydrochloride with an alkali metallic salt of a 6β-halopenicillanic acid under heating.
CONSTITUTION: Bacampicillin hydrochloride is reacted with an alkali metallic salt or an amine salt of a 6β-halopenicillanic acid shown by the formula I (X is halogen) under heating preferably at 30W50°C usually for 0.5W2hr, to give the aimed compound shown by the formula II. Na salt is preferably as the salt of the compound shown by the formula I. Water, etc. are used as a reaction solvent.
Inventors:
ARAKI KAZUHIKO
UEMORI SATORU
KURODA TAKESHI
MORIGUCHI AKIHIKO
UEMORI SATORU
KURODA TAKESHI
MORIGUCHI AKIHIKO
Application Number:
JP15736385A
Publication Date:
January 28, 1987
Filing Date:
July 17, 1985
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL
International Classes:
C07D499/87; C07D499/00; C07D499/14; C07D499/64; C07D499/68; C07D499/86; C07D499/897; (IPC1-7): C07D499/00; C07D499/14; C07D499/68
Attorney, Agent or Firm:
Takamiya Castle Masaru