Title:
PRODUCTION OF BENZOIC ACID AMIDES
Document Type and Number:
Japanese Patent JP3463919
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To produce the subject amide corresponding to a raw material from a readily available aromatic halide and useful as an intermediate for medicines and agrochemicals in a one-stage reaction by uysing ammonia under specific conditions.
SOLUTION: (A) An aromatic compound represented by formula I [X is a halogen, trifluoromethanesulfonate or the like; R is trifluoromethyl, trifluoromethyloxy or the like; (n) is O or 1-3], preferably 3,5-bis(trifluoromethyl) bromobenzene is reacted with (D) carbon monoxide and (E) ammonia in the presence of (B) a group VIII metal of the periodic table (preferably palladium, etc.), and (C) phosphines to produce an amide represented by formula II. Furthermore, a phosphine represented by the formula P(L)3 (L is a lower alkyl, phenyl or the like) or the formula (R1)2P-Q-P(R1)2 (R1 is phenyl, o-methylphenyl or the like; Q is a bivalent group) is preferably used as the component C.
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Inventors:
Takashi Kume
Michio Ishida
Satoshi Naritsuka
Yuzuru Morino
Makoto Koide
Michio Ishida
Satoshi Naritsuka
Yuzuru Morino
Makoto Koide
Application Number:
JP35152898A
Publication Date:
November 05, 2003
Filing Date:
December 10, 1998
Export Citation:
Assignee:
Central Glass Co., Ltd.
International Classes:
B01J31/24; C07B61/00; C07C231/10; C07C233/65; (IPC1-7): C07C231/10; B01J31/24; C07C233/65
Domestic Patent References:
| JP8104661A | ||||
| JP63227547A | ||||
| JP646238A | ||||
| JP5479274A | ||||
| JP2000169435A |
Attorney, Agent or Firm:
Yoshiyuki Nishi