Title:
PRODUCTION OF CARNITINE INTERMEDIATE
Document Type and Number:
Japanese Patent JPS62212352
Kind Code:
A
Abstract:
PURPOSE: The reaction of S-chloromethyloxirane with trimethylamine gives S-3-chlor-3-hydroxypropyltrimethylammonium chloride which is used as a syn thetic intermediate of carnitine in high yield.
CONSTITUTION: S-Chloromethyloxirane of formula I is allowed to react with trimethylamine hydrochloride to give 3-chlor-2-hydroxypropyltrimethyl-ammonium chloride. The compound of formula I is obtained by selective hydrolysis of the S-isomer of a glycerol derivative of formula III (R is 1W8C aliphatic hydrocarbon; R' is aromatic hydrocarbon) with lipase into an equimolar mixture of unreacting ester (R) of formula IV and an alcohol (S) of formula V, epoxidizing only the S-isomer by treatment with a base and separating the product by distillation.
Inventors:
KOBAYASHI MAKOTO
HAMAGUCHI SHIGEKI
KATAYAMA KAZUHIKO
OHASHI TAKEHISA
WATANABE KIYOSHI
HAMAGUCHI SHIGEKI
KATAYAMA KAZUHIKO
OHASHI TAKEHISA
WATANABE KIYOSHI
Application Number:
JP5521586A
Publication Date:
September 18, 1987
Filing Date:
March 11, 1986
Export Citation:
Assignee:
KANEGAFUCHI CHEMICAL IND
International Classes:
C07B53/00; C07B31/00; C07C67/00; C07C213/00; C07C213/04; C07C215/40; C12P11/00; (IPC1-7): C07B53/00; C07C89/02; C07C91/26; C12P11/00
Attorney, Agent or Firm:
Shinichi Asano