Title:
PRODUCTION OF CEPHALEXIN
Document Type and Number:
Japanese Patent JPH044896
Kind Code:
A
Abstract:
PURPOSE: To industrially and efficiently obtain the title cephalexin useful as an antibiotic in a biological method by adding penicillin acylase produced by the Xanthomonas to a reaction system.
CONSTITUTION: When 7-aminodesacetoxycephalosporonic acid is reacted with phenylglycin and reactive derivative thereof, Penicillin acylase produced by Xanthomonas sp. YT-1099 strain (FERM P-11401) is added to the reaction system to provide the aimed cephalexin. Furthermore, the above-mentioned enzyme is preferably obtained from a cultured mixture obtained by culturing the above- mentioned microbial strain in a nutrient medium at pH 6-7 and 25-30°C for 12-20 hr.
Inventors:
KURATA KEIJI
OKUMOTO YASUSHI
MURAKAMI KATSUMI
IKEDA TAKASHI
YAMAMOTO KATSUHIRO
IIMORI KATSUYOSHI
OKUMOTO YASUSHI
MURAKAMI KATSUMI
IKEDA TAKASHI
YAMAMOTO KATSUHIRO
IIMORI KATSUYOSHI
Application Number:
JP10574290A
Publication Date:
January 09, 1992
Filing Date:
April 20, 1990
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL
International Classes:
C12N9/80; C12P35/04; C12R1/64; (IPC1-7): C12P35/04
Attorney, Agent or Firm:
Takamiya Castle Masaru