PRODUCTION OF D-CHIRO-INOSITOL - Hokuko Chemical Industry Co., Ltd.

Title:

PRODUCTION OF D-CHIRO-INOSITOL

Document Type and Number:

Japanese Patent JP3053510

Kind Code:

B2

Abstract:

PURPOSE: To provide a method for producing D-chiro-inositol in high purity with hardly any side reaction by simply and efficiently hydrolyzing of kasugamycin under mild acidic conditions.
CONSTITUTION: This method for producing D-chiro-inositol is to mix an aqueous solution of kasugamycin hydrochloride or sulfate with a granular strong acidic ion exchange resin (H+ type), provide an adduct of a strongly acidic ion exchange resin to kasugamycin as a granular salt, mix the resultant substance with a 0.05-0.5 N, preferably 0.15-0.2 N aqueous solution of free hydrochloric acid or sulfuric acid, heat the prepared mixture under atmospheric or a higher pressure, hydrolyze the kasugamycin, from a reactional solution containing D-chiro-inositol and the hydrochloric acid or sulfuric acid, cool the reactional solution, separate the solution from the resin, mix wash water of the resin with the reactional solution, pass the resultant acidic mixture solution through a column filled with a basic ion exchange resin (OH- type), afford a neutral eluate containing the D-chiro-inositol, concentrate the eluate, deposit a crystal or continuously introduce the aqueous solution of kasugamycin hydrochloride or sulfate through a column filled with the strong acidic ion exchange resin (H+ type) under heated conditions and hydrolyze the kasugamycin.

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Inventors:

Kiyoshi Sato
Makoto Yoshida
Kenji Kanbe
Kiyoshi Hirasawa
Tomio Takeuchi

Application Number:

JP21792693A

Publication Date:

June 19, 2000

Filing Date:

August 11, 1993

Export Citation:

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Assignee:

Hokuko Chemical Industry Co., Ltd.
Foundation for Microbial Chemistry

International Classes:

C07C29/10; C07C29/76; C07C29/78; C07C35/16; (IPC1-7): C07C29/10; C07C29/76; C07C29/78; C07C35/16

Domestic Patent References:

JP311026A
JP6156142A
JP56138125A
JP3718476B1

Attorney, Agent or Firm:

Shigeru Yagita (2 outside)

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