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Title:
PRODUCTION OF DOPA DERIVATIVE
Document Type and Number:
Japanese Patent JPS5632443
Kind Code:
A
Abstract:

PURPOSE: A β-lactam is hydrogenolyzed in the presence of a palladium catalyst to produce the title compound used as a remedy for Partkinson's diseases from an inexpensive starting material through shortened process in high yield.

CONSTITUTION: In the presence of a palladium catalyst, the hydrogenolysis of a β- lactam of formula I (R1, R2 are H, alkyl, benzyl, acyl and they may incorporate to form alkylene; R3 is alkyl, aryl, aromatic heterocycle; X is amino, azide) is effected to produce a dopa derivative of formula II. As the palladium catalyst, Pd-C is preferred, because the palladium metal is well dispersed and it is high effective even in a small amount and the amount is usually 1W50% based on the β-lactam (calculated as palladium metal). The reaction pressure is preferably 1W20 atmospheric one, because it is easy-to-operate.


Inventors:
OSHIMA IWAO
SUGA SHIGEI
ABE RUMIKO
Application Number:
JP10360179A
Publication Date:
April 01, 1981
Filing Date:
August 16, 1979
Export Citation:
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Assignee:
SAGAMI CHEM RES
International Classes:
C07D317/60; B01J23/00; B01J23/44; C07B61/00; C07C67/00; C07C227/18; C07C229/36; C07C231/00; C07C231/08; C07C237/20; (IPC1-7): B01J23/44; C07C101/30; C07C102/00; C07C103/85; C07D317/60



 
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