PRODUCTION OF FLUORO COMPOUND

Title:

PRODUCTION OF FLUORO COMPOUND

Document Type and Number:

Japanese Patent JPH09241190

Kind Code:

A

Abstract:

To obtain a fluoro compound useful as an intermediate for medicines by fluorinating a benzyl alcohol derivative with a specific fluorinating agent in the presence of triethylamine and hydrogen fluoride.

A benzyl alcohol derivative of formula I (R1 is H, a lower alkyl, a lower alkenyl, a lower alkoxyalkyl, a lower alkoxycarbonylalkyl, etc.; R2 is H, piperazinyl, piperidyl, pyrrolidinyl, etc.; R3 and R4 are each H, a halogen, cyano, a lower alkyl, etc.) is reacted with N,N-diethyl-1,1,2,3,3,3- hexafluoropropylamine in the presence of triethylamine and hydrogen fluoride to give a fluorinated benzyl derivative of formula II.

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Inventors:

SHIMIZU JUICHI
NAGAOKA MUTSUMI
ODA MITSUO
SEKI CHIAKI
YAMASHITA TSUNEO
SHIMOKAWA KAZUHIRO

Application Number:

JP5045396A

Publication Date:

September 16, 1997

Filing Date:

March 07, 1996

Export Citation:

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Assignee:

EISAI KAGAKU KK
DAIKIN IND LTD

International Classes:

C07D295/08; C07B39/00; C07C17/16; C07C19/08; C07C22/08; C07C23/20; C07C23/28; C07C23/38; C07C253/30; (IPC1-7): C07C22/08; C07B39/00; C07C17/16; C07C19/08; C07C23/20; C07C23/28; C07C23/38; C07D295/08

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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