Title:
PRODUCTION OF FUMARIC ACID
Document Type and Number:
Japanese Patent JP3709007
Kind Code:
B2
Abstract:
PURPOSE: To efficiently produce fumaric acid useful for foods, medicines, industrial raw materials, etc., by suppressing the dissolved oxygen concentration to a specific value or below and carrying out the isomerizing reaction of a microorganism (a prepared substance) having maleic isomerase activities with maleic acid in an aqueous solution.
CONSTITUTION: A microorganism having maleic isomerase activities (e.g. Alcaligenes faecalis IFO12669 strain) or a prepared substance thereof is mixed with maleic acid in an aqueous solution and the resultant reactional solution is then sealed with one or more gases such as N2, Ar or He to maintain the dissolved oxygen in the reactional solution at ≤4ppm. Enzymic isomerizing reaction is then carried out to isomerize the maleic acid into fumaric acid. Thereby, the objective fumaric acid useful as a raw material for producing L-aspartic acid, L-malic acid, L-alanine, etc., useful as foods, medicines or industrial raw materials is efficiently obtained in high yield.
Inventors:
Makoto Goto
Tokumaru
Terazawa Masato
Hideaki Yukawa
Tokumaru
Terazawa Masato
Hideaki Yukawa
Application Number:
JP9630496A
Publication Date:
October 19, 2005
Filing Date:
March 26, 1996
Export Citation:
Assignee:
Mitsubishi Chemical Corporation
International Classes:
C12P7/46; C12P13/20; C12R1/05; C12R1/07; C12R1/08; C12R1/39; C12R1/64; (IPC1-7): C12P7/46
Domestic Patent References:
| JP427396A | ||||
| JP6143993A |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
Masazumi Imamura
Toshio Shiozawa
Masazumi Imamura
Toshio Shiozawa
Previous Patent: DEVICE AND METHOD FOR DRIVING
Next Patent: ROUTE CALCULATION DEVICE AND METHOD THEREFOR
Next Patent: ROUTE CALCULATION DEVICE AND METHOD THEREFOR