Title:
PRODUCTION OF HOMOSTEROIDS
Document Type and Number:
Japanese Patent JPS5422356
Kind Code:
A
Abstract:
D-Homo oxasteroids and processes for their preparation, which can be used as anti-inflammatory agents, the steroids having the formula or the 1,2-dehydro derivative thereof; wherein R1 is hydrogen, alkyl-@-O-, aryl-@-O-, halogen or hydroxy; R2is hydrogen or alkyl; R3 is alkyl; R4 is carbonyl, beta -hydroxymethylene, beta -chloromethylene or beta -bromomethylene; R5 is hydrogen, fluorine, chlorine or bromine; R6 is hydrogen, fluorine or methyl; and R7 is hydrogen, chlorine or bromine; with the proviso that when R1 is hydroxy, R2 is alkyl; and with the further proviso that when R2 is alkyl, it is the same alkyl group as R3; wherein aryl is phenyl or phenyl substituted with one or two alkyl, alkoxy or halogen groups; and alkyl and alkoxy are groups having 1 to 10 carbon atoms.
Inventors:
KURISUTOFUA MITSUCHIERU SHIMAR
POORU GURABOUITSUCHI
RABI KANNAJIKOBIRAKOMU BAAMA
POORU GURABOUITSUCHI
RABI KANNAJIKOBIRAKOMU BAAMA
Application Number:
JP8926978A
Publication Date:
February 20, 1979
Filing Date:
July 20, 1978
Export Citation:
Assignee:
SQUIBB & SONS INC
International Classes:
A61K31/35; A61K31/352; C07D311/78; A61P29/00; C07J73/00; (IPC1-7): A61K31/35; C07D311/78