Title:
PRODUCTION OF HUMAN PARATHYROID HORMONE WITH MICROORGANISM
Document Type and Number:
Japanese Patent JP2834111
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new vector, having a DNA capable of coding a prathyroid hormone and a gene containing a DNA, operably bonded thereto and capable of coding a Saccharomyces mating factor alpha 1 and useful for transforming a microbial host and expressing and producing the parathyroid hormone.
SOLUTION: This new vector has a DNA capable of coding a parathroid hormone(PTH) containing a nucleotide sequence of the formula, etc., and a gene containing a DNA, operably bonded thereto and capable of coding a Saccharomyces mating factor alpha 1 and is capable of transforming a microbial host, expressing the parathyroid hormone and secreting the parathyroid hormone. The vector is useful for the stable production, etc., of a yeast, etc., of a nontoxic human parathyroid hormone effective in treatment of osteoporosis, measurement of the parathyroid hormone level in humans or animals, treatment, etc., of an abnormality in blood calcium level using the microbial host.
Inventors:
PEETERU ARESUTOROOMU
KAARE ENMU GAUTOBIKU
TORUDEISU BEATE OIEN
OODO SUTOOKU GABURIERUSEN
KAARE ENMU GAUTOBIKU
TORUDEISU BEATE OIEN
OODO SUTOOKU GABURIERUSEN
Application Number:
JP8292197A
Publication Date:
December 09, 1998
Filing Date:
April 01, 1997
Export Citation:
Assignee:
KAARE ENMU GAUTOBIKU
PEETERU ARESUTOROOMU
PEETERU ARESUTOROOMU
International Classes:
C12N15/09; C07K14/575; C07K14/635; C12N1/19; C12N1/21; C12N15/00; C12N15/16; C12N15/64; C12N15/66; C12N15/67; C12N15/70; C12N15/81; C12P21/02; A61K38/00; C12R1/19; C12R1/865; (IPC1-7): C12N15/09; C12N1/19; C12N1/21; C12P21/02
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)