Title:
Production and its use of IFN -lambda by a former type dendritic cell
Document Type and Number:
Japanese Patent JP6263559
Kind Code:
B2
Abstract:
In the present invention, CD8+ conventional dendritic cells (CD8+ cDCs) and equivalents thereof (eCD8+ cDCs) in mouse and human have been established as major source of IFN-lambda (IFN-λ) in response to double-stranded (ds) nucleic acids. The invention relates to therapeutic applications of ds nucleic acids or analogs thereof targeting CD8+ and/or eCD8+ cDCs in the prevention and/or treatment of infectious diseases, preferably viral infections, or cancer. Furthermore, the invention relates to an in vitro method for producing IFN-λ and/or generating or obtaining a population of IFN-λ producing CD8+ or eCD8+ cDCs as well as in vitro method for detecting or screening for CD8+ and/or eCD8+ cDCs. In addition, the invention relates to a Flt3-ligand or a M-CSF receptor ligand for use in increasing the level of CD8+ and/or eCD8+ cDCs in a subject suffering from an infectious disease or cancer.
More Like This:
Inventors:
Hoholin Hubertus
Application Number:
JP2016001627A
Publication Date:
January 17, 2018
Filing Date:
January 07, 2016
Export Citation:
Assignee:
Bavarian Nordic Actiselskab
International Classes:
C12Q1/04; A61K35/15; C12N5/0784; C12N15/09
Domestic Patent References:
| JP7507997A | ||||
| JP2004517807A | ||||
| JP2008507530A | ||||
| JP2006512391A |
Foreign References:
| WO2009088401A1 | ||||
| WO2006054177A1 | ||||
| WO2008109083A1 | ||||
| WO2009102496A1 | ||||
| WO2008131926A1 |
Other References:
J. Immunol., 2009.08, Vol.183, p.2522-2528
Journal of Virology,2009年 9月 9日,Vol.83,No.23,p.12266-12278
Gene Therapy,2005年,Vol.12,p.1394-1404
J. Immunol., 2008, Vol.180, p.2474-2485
Blood, 2002, Vol.99, No.6, p.2122-2130
Experimental and Molecular Medicine, 2009.02, Vol.41, No.2, p.61-66
Nature, 2005, Vol.433, 887-892
Nature Immunology, 2002, Vol.4, No.1, p.63-68
Journal of Virology,2009年 9月 9日,Vol.83,No.23,p.12266-12278
Gene Therapy,2005年,Vol.12,p.1394-1404
J. Immunol., 2008, Vol.180, p.2474-2485
Blood, 2002, Vol.99, No.6, p.2122-2130
Experimental and Molecular Medicine, 2009.02, Vol.41, No.2, p.61-66
Nature, 2005, Vol.433, 887-892
Nature Immunology, 2002, Vol.4, No.1, p.63-68
Attorney, Agent or Firm:
Mitsufumi Esaki
Blacksmith
Katsunori Uenishi
Ichiro Torayama
Blacksmith
Katsunori Uenishi
Ichiro Torayama
Previous Patent: A processing unit using the sterilization substance for the lids of a container
Next Patent: PRODUCTION OF POROUS CERAMIC PRODUCT
Next Patent: PRODUCTION OF POROUS CERAMIC PRODUCT