Title:
PRODUCTION OF LABELED COMPOUND
Document Type and Number:
Japanese Patent JP3896477
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the labeled compound for pyruvic acid useful for imaging, clinical diagnosis, research, etc., by treating a D,L-alanine whose carbon at the 3-position is substituted with an isotope with an alanine racemase and a pyruvic acid-forming enzyme.
SOLUTION: This method for producing a labeled compound in which pyruvic acid whose carbon at the 3-position is substituted with 11C, 13C or 14C isotope or its salt comprises treating a D,L-alanine whose carbon at the 3-position is substituted with 11C, 13C or 14C isotope or its salt with an immobilized enzyme obtained by immobilizing an alanine racemase [EC.5.1.1.1] and an enzyme (e.g. D-amino acid oxidase [EC.1.4.3.3], etc.) which is treated with alanine to form pyruvic acid to a proper immobilizing carrier to efficiently obtain a labeled compound of pyruvic acid (salt) useful for tumor and brain imaging, clinic diagnosis, functional research of organisms, etc.
Inventors:
Masahiro Ikemoto
Keigo Komura
Furuya Yuji
Motohito Sasaki
Yasuyoshi Watanabe
Suzuki Kazutoshi
Keigo Komura
Furuya Yuji
Motohito Sasaki
Yasuyoshi Watanabe
Suzuki Kazutoshi
Application Number:
JP11459297A
Publication Date:
March 22, 2007
Filing Date:
May 02, 1997
Export Citation:
Assignee:
Ikeda Shokuken Co., Ltd.
Sumitomo Heavy Industries Ltd.
Osaka Bioscience Institute
National Institute of Radiological Sciences
Sumitomo Heavy Industries Ltd.
Osaka Bioscience Institute
National Institute of Radiological Sciences
International Classes:
C12P7/40; A61K51/00; C07C59/19; (IPC1-7): C12P7/40; A61K51/00; C07C59/19
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Kyousei Tamura