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Title:
PRODUCTION OF METAL COMPLEXES OF N-BETA-HYDROXYALKYL-TRI-N-CARBOXYLALKY-1,4,7,10-TETRAAZACYCLODODECANE AND N-BETA-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECANE-DERIVATIVE
Document Type and Number:
Japanese Patent JP3727359
Kind Code:
B2
Abstract:

PURPOSE: To industrially and advantageously produce in short process N-β- hydroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecanes or the like important as an NMR diagnostic.
CONSTITUTION: The intermediate of formula III (R2 is formula IV) is obtained by reacting a compound of formula I (n is 2 or 3) which is obtained from 1,4,7,10- tetraazacyclodecane or 1,4,8,11-tetraazacyclotetradecane with an epoxide of formula II (R4 and R5 are each H or alkyl). A compound of formula VI is obtained by saponifying the resultant intermediate of formula III to form an intermediate of formula V and reacting it with a compound of the formula; X-CH2COOH (X is an eliminable group; Z is H, a metal cation or the like) in the presence of an acid scavenger. Then a metal complex of the compound of formula IV, an inorganic and/or organic base, an amino acid or amino acid amide and their salts are obtained by the reaction of the compound of formula VI with a metal oxide or a metal salt of an element with atomic number of 21 to 23, 37 to 39, 42 to 51 or 57 to 83. The process gives a high yield and need not isolation and purification of the intermediate.


Inventors:
ヨハネス プラツェク
ハインツ グリース
Application Number:
JP1993000276577
Publication Date:
December 14, 2005
Filing Date:
November 05, 1993
Export Citation:
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Assignee:
Schering Aktiengesellschaft
International Classes:
C07D257/02; C07F5/00; (IPC1-7): C07D257/02; C07F5/00
Domestic Patent References:
JP64052764A
JP4288063A
JP4120065A
Foreign References:
Attorney, Agent or Firm:
矢野 敏雄
山崎 利臣
ラインハルト・アインゼル