To provide a method for producing an alkylimidazole at least having substituent groups at the first and second positions while producing only a small amount of a by-product being imidazole having no substituent group at the second position.
The production method of an alkylimodazole (E) represented by general formula (1) is characterized by the reaction of a glyoxal or its acetal or its ketal (a), an aldehyde (b), a primary amine (c), and ammonia (d) in the presence of an acid (f). Preferably, after inputting a part of a mixture of (c) and (d), the residue of the mixture of (c) and (d) and a mixture of (a) and (b) are simultaneously dropped. The acid (f) is preferably an acid having a pKa of 4 or lower and is preferably p-toluenesulfonic acid or sulfuric acid.
COPYRIGHT: (C)2007,JPO&INPIT
NAKAYA YOSHIFUMI
| JPS62164672A | 1987-07-21 | |||
| JP2004513941A | 2004-05-13 | |||
| JPS5661359A | 1981-05-26 | |||
| JP2004513941A | 2004-05-13 | |||
| JP2004207451A | 2004-07-22 | |||
| JPS62164672A | 1987-07-21 |
JPN6012007861; ＧＥＬＥＮＳ，Ｅ． ｅｔ ａｌ: 'Ｅｆｆｉｃｉｅｎｔ ｌｉｂｒａｒｙ ｓｙｎｔｈｅｓｉｓ ｏｆ ｉｍｉｄａｚｏｌｅｓ ｕｓｉｎｇ ａ ｍｕｌｔｉｃｏｍｐｏｎｅｎｔ ｒｅａｃｔｉｏｎ ａｎｄ ｍｉｃｒｏｗａｖｅ ｉｒｒａｄｉａｔｉｏｎ' Ｍｏｌｅｃｕｌａｒ Ｄｉｖｅｒｓｉｔｙ Ｖｏｌ．１０， Ｎｏ．１, 2006, ｐ．１７-２２
JPN6012007861; ＧＥＬＥＮＳ，Ｅ． ｅｔ ａｌ: 'Ｅｆｆｉｃｉｅｎｔ ｌｉｂｒａｒｙ ｓｙｎｔｈｅｓｉｓ ｏｆ ｉｍｉｄａｚｏｌｅｓ ｕｓｉｎｇ ａ ｍｕｌｔｉｃｏｍｐｏｎｅｎｔ ｒｅａｃｔｉｏｎ ａｎｄ ｍｉｃｒｏｗａｖｅ ｉｒｒａｄｉａｔｉｏｎ' Ｍｏｌｅｃｕｌａｒ Ｄｉｖｅｒｓｉｔｙ Ｖｏｌ．１０， Ｎｏ．１, 2006, ｐ．１７-２２
JPN6012007862; Ｓｅｐｅｈｒ Ｓａｒｓｈａｒ ｅｔ ａｌ: 'Ｉｍｉｄａｚｏｌｅ ｌｉｂｒａｒｉｅｓ ｏｎ ｓｏｌｉｄ ｓｕｐｐｏｒｔ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．３７， Ｎｏ．６, 1996, ｐ．８３５-８３８
Next Patent: PRODUCTION METHOD OF CYCLOBUTALENE