Title:
ナプロキセンのニトロオキシ誘導体の製造法
Document Type and Number:
Japanese Patent JP4528123
Kind Code:
B2
Abstract:
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.
Inventors:
Del Soldato, Clown
Giancarlo, Santas
Benedini, Franceska
Giancarlo, Santas
Benedini, Franceska
Application Number:
JP2004532054A
Publication Date:
August 18, 2010
Filing Date:
August 06, 2003
Export Citation:
Assignee:
NICOX S.A.
International Classes:
A61K31/618; C07C201/04; A61K31/216; C07B61/00; C07C67/10; C07C69/734; C07C201/02; C07C201/08; C07C203/00; C07C203/04; C07C269/06; C07C271/28
Domestic Patent References:
| JP5279359A | ||||
| JP9503214A |
Foreign References:
| WO2001010814A1 |
Other References:
Yutaka Kawashima et al.,Synthesis and Pharmacological Evaluation of (Nitrooxy)alkyl Apovincaminates,J.Med.Chem,1993年,36,第815-819頁
Toshihisa Ogawa et al.,Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Derivatives Containing Nitrooxyalkylester Moieties at the 3- and 5-Positions,Chem.Pharm.Bull.,1993年,41(6),第1049-1054頁
Ashraf H.Abadi et.al,Synthesis and Cyclooxygenase Inhibitory Properties of Novel (+)2-(6-Methoxy-2-naphthyl)propanoic Acid(Naproxene)Derivatives,Arch. Pharm. Pharm. Med. Chem,2001年,第104-106頁
Claudio Glordano et al.,A stereoconvergent strategy for the synthesis of enantiomerically pure (R)-(-) and (S)-(+)-2-(6-methoxy-2-naphthyl)-propanoic acid (Naproxen) ,Tetrahedron,1989年,Vol.45, No.13,第4243-4252頁
Toshihisa Ogawa et al.,Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Derivatives Containing Nitrooxyalkylester Moieties at the 3- and 5-Positions,Chem.Pharm.Bull.,1993年,41(6),第1049-1054頁
Ashraf H.Abadi et.al,Synthesis and Cyclooxygenase Inhibitory Properties of Novel (+)2-(6-Methoxy-2-naphthyl)propanoic Acid(Naproxene)Derivatives,Arch. Pharm. Pharm. Med. Chem,2001年,第104-106頁
Claudio Glordano et al.,A stereoconvergent strategy for the synthesis of enantiomerically pure (R)-(-) and (S)-(+)-2-(6-methoxy-2-naphthyl)-propanoic acid (Naproxen) ,Tetrahedron,1989年,Vol.45, No.13,第4243-4252頁
Attorney, Agent or Firm:
Shintaro Nogawa