To produce an optically active amino acid and an optically active N-alkoxycarbonylamino acid which can obtain an optically active amino acid and an optically active N-alkoxycarbonylamino acid with good yield.
After a pH of an aqueous solution including racemic amino acid amide is adjusted by an acid in the vicinity of neutral, enantioselective hydrolysis reaction by amidase of amino acid amide is carried out. Afterwards, in a production method for an optically active amino acid, an inorganic base compound of an amount of mol with which the acid is almost neutralized is added in the aqueous solution, and furthermore, an optically active amino acid is crystalized and recovered by substituting the solvent of the aqueous solution from water by the solvent of an alcohol with three or more carbons. A production method for an optically active N-alkoxycarbonylamino acid uses a raw material of optically active N-alkoxycarbonylamino acid production without purification operation of optically active amino acid which is recovered from a hydrolysis reaction solution.
MORI HIROYUKI
| JP2001328970A | 2001-11-27 | |||
| JP2001011034A | 2001-01-16 |
| WO2006115194A1 | 2006-11-02 |
JPN6012011085; Ｊ． Ｍｅｄ． Ｃｈｅｍ． １９９８， ４１， ３３８７-３４０１
Keiko Kanemoto
Reiko Tanaka
Ken Kitano
Natsuki Ito
Yuko Matsuniya
Umeda Shinsuke
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