Title:
PRODUCTION METHOD OF TOFISOPAM, INTERMEDIATE THEREOF, AND PRODUCTION METHOD OF THE INTERMEDIATE
Document Type and Number:
Japanese Patent JP2020023446
Kind Code:
A
Abstract:
To provide: a method for performing optical carboxylation of o-alkyl benzophenone at a high reaction rate and high yield by a simpler operation; and a method for producing tofisopam at low cost.SOLUTION: There is produced 2,3-benzodiazepine derivative (tofisopam) by producing a compound (B) by performing light irradiation of a compound (A) in the presence of a Cs base and CO, followed by sequential reaction with hydrazine, a halogenation agent, and methyl lithium.SELECTED DRAWING: None
Inventors:
MURAKAMI MASAHIRO
MASUDA YUSUKE
ISHIDA NAOKI
MASUDA YUSUKE
ISHIDA NAOKI
Application Number:
JP2018147745A
Publication Date:
February 13, 2020
Filing Date:
August 06, 2018
Export Citation:
Assignee:
MURAKAMI MASAHIRO
International Classes:
C07C51/15; A61K31/551; A61P25/00; A61P25/04; C07C59/90; C07D243/02
Attorney, Agent or Firm:
Tomohiro Sakamoto
Ayumi Yada
Hirofumi Aoki
Ayumi Yada
Hirofumi Aoki